Effects of Neurorehabilitation Program on Cognitive Function in Cancer Survivors: A Meta-Analysis

Purpose: Cancer survivors frequently experience chemotherapy-related cognitive impairment (CRCI), which contributes to difficulties in memory and thinking. Effective rehabilitation programs are therefore essential to help survivors manage CRCI and improve quality of life.Methods: A systematic search of CINAHL, Cochrane Library, PubMed, and Embase identified studies that met predefined criteria based on participant, intervention, comparison, outcome, and study design. The primary outcome was analyzed using a random-effects model with statistical significance set at <i>p</i><.05. Heterogeneity was assessd using the I2 statistic.Results: Of 10,288 screened studies, 10 met the inclusion criteria. Neurocognitive rehabilitation programs showed a small but statistically significant overall effect on cognitive function (Hedges' g=0.45, 95% CI=0.29~0.61, Z=5.57, <i>p</i><.001). Subgroup analyses indicated significant effects for both overall cognitive function and specific cognitive domains (<i>p</i><.001).Conclusion: Neurorehabilitation programs are effective in enhancing cognitive function among cancer survivors, with optimal outcomes observed in interventions delivered for one to two hours per session over five to seven weeks.