The distinct contribution of sternotomy to the systemic inflammatory response during children's heart surgery
Sternotomy and related tissue trauma produce a distinct systemic inflammatory mediator profile, consisting of pro-inflammatory cytokines and chemokines but not complement. The mediators IL-6, CXCL8, IL-1Ra and IL-10 are sequentially induced by both sternotomy and CPB, representing sequential immunologic stimulation during the cardiac operation.
Authors
- Julia Paffile
- Mark J. Henderson (ORCID: https://orcid.org/0000-0002-2262-8777)
- Roger Stanzel
- Joel Bierer (ORCID: https://orcid.org/0000-0002-4579-5674)
- David J. Horne (ORCID: https://orcid.org/0000-0002-2148-437X)
- Pantelis Andreou
- J. Sapp
- Jean Sylvia Marshall
Institutions
- Dalhousie University (CA)
- Nova Scotia Health Authority (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1617524
- Primary Topic
- Cardiac and Coronary Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- IWK Health Centre