Ferula ammoniacum gum aqueous extract exerts anti-inflammatory and antioxidant mechanisms to combat aluminum chloride-induced Alzheimer’s disease in rats: possible involvement of opioid pathways
Behavioral, biochemical, and histopathological impairments induced by AlCl<sub>3</sub> were significantly attenuated by FAGAE, possibly through the opioidergic pathway, which combats inflammation and oxidative stress and supports neuronal survival.
Authors
- Sajad Fakhri (ORCID: https://orcid.org/0000-0001-8265-8284)
- Javier Echeverría
- Mohammad Mehdi Gravandi (ORCID: https://orcid.org/0000-0002-7995-5285)
- Mohammad Bagher Majnooni (ORCID: https://orcid.org/0000-0001-5053-333X)
- Mohammad Hosein Farzaei
- Fatemeh Abbaszadeh
- Khodabakhsh Rashidi
Institutions
- Universidad de Santiago de Chile (CL)
- Kermanshah University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fphar.2025.1708643
- Citations
- 1
- Primary Topic
- Aluminum toxicity and tolerance in plants and animals
- Type
- article
- Field-Weighted Citation Impact
- 31.34
Funders
- Kermanshah University of Medical Sciences