A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols

Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-nitro alcohols bearing two stereocenters. Optimization of each step enabled the efficient and selective formation of all four diastereomers with excellent stereoselectivity (up to 97:3 dr and er) and good yields. This work highlights the potential of multicatalytic cascades for the synthesis of stereochemically rich molecules.