Modular Synthesis of Densely Functionalized Azetidines: Ni-Catalyzed 1,4-Alkylarylation of 1,3-Enynes with 1-Azabicyclo[1.1.0]butanes through Polar–Radical Relay
An efficient synthesis of densely functionalized azetidines has been achieved via a Ni-catalyzed 1,4-alkylarylation of 1,3-enynes using 1-azabicyclo[1.1.0]butanes (ABBs) and arylboronic acids. This three-component reaction offers an easy way to incorporate an allene fragment into azetidines. The method is characterized by a broad substrate scope and excellent functional group compatibility. Mechanistic studies have revealed a polar-radical relay mechanism for this transformation.
Authors
- Li‐Na Guo (ORCID: https://orcid.org/0000-0002-9789-6952)
- Wentao Zhang (ORCID: https://orcid.org/0000-0002-0903-3306)
- Kuan Zhang (ORCID: https://orcid.org/0009-0005-2878-4542)
- Xin-Hua Duan
- Zhengyang Gao
Institutions
- State Key Laboratory of Chemical Engineering (CN)
- Lanzhou University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c04841
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 22.95