Attenuated viral strains of priority pathogens for potential use in controlled human infection model studies: A scoping review
We have identified three attenuated viral strains that may be amenable to development into novel CHIMs for two priority pathogens. Of these, VLA1553 for chikungunya is a licenced and commercially available vaccine product suitable for use in CHIM. There is a research gap for the creation of new attenuated mutants that could be utilised in CHIM for other priority pathogens.
Authors
- Vittoria Lutje (ORCID: https://orcid.org/0000-0001-6815-3239)
- Daniela M. Ferreira (ORCID: https://orcid.org/0000-0002-0594-0902)
- Victoria Simpson (ORCID: https://orcid.org/0000-0003-3402-6711)
- Alain Kohl
- Tilly Fox
- Ben Morton
- David Oliver Hamilton
Institutions
- Liverpool School of Tropical Medicine (GB)
- University of Oxford (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1371/journal.pntd.0013243
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00