Analysis of common differential gene expression between rheumatoid arthritis and ulcerative colitis

The results of this study reveal potential common molecular mechanisms underlying rheumatoid arthritis (RA) and ulcerative colitis (UC). The key target genes CCR7, CD19, CXCL13, CXCR4, and SELL highlight common underlying factors associated with both diseases. Further investigation and exploration of these findings can pave the way for new candidate targets and directions in therapeutic research aimed at treating RA and UC. This study emphasizes the importance of utilizing bioinformatics approaches to uncover the mechanisms of complex diseases, providing a promising pathway for the development of more effective and targeted treatments.

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Publication Details

Journal
PLoS ONE
Published
2026-01-02
DOI
https://doi.org/10.1371/journal.pone.0339397
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
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article

Analysis of common differential gene expression between rheumatoid arthritis and ulcerative colitis

Chang-sheng Liao, Weirong Cui, Fang-zheng He, Tao Wu et al.
PLoS ONE
Rheumatoid Arthritis Research and Therapies
article

Analysis of common differential gene expression between rheumatoid arthritis and ulcerative colitis

Chang-sheng Liao, Weirong Cui, Fang-zheng He, Tao Wu, Peng-fei Han
article en

Abstract

The results of this study reveal potential common molecular mechanisms underlying rheumatoid arthritis (RA) and ulcerative colitis (UC). The key target genes CCR7, CD19, CXCL13, CXCR4, and SELL highlight common underlying factors associated with both diseases. Further investigation and exploration of these findings can pave the way for new candidate targets and directions in therapeutic research aimed at treating RA and UC. This study emphasizes the importance of utilizing bioinformatics approaches to uncover the mechanisms of complex diseases, providing a promising pathway for the development of more effective and targeted treatments.

PLoS ONEVol. 21(1)
Changzhi Medical College (CN)
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Openalex Percentile: Top 99%
Rheumatoid Arthritis Research and Therapies
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