Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality in mice by increasing M1 macrophage polarization and cytokine production
EV-A71 infection enhances IL-20RA cytokines, which then increase viral loads and aggravate disease severity in WT mice by elevating the T cell-IL-10-M2 macrophage axis and suppressing the protective M1 macrophage-IL-12-macrophage-IFN-γ axis. This represents a previously unreported mechanism.
Authors
- C. Liu
- Yi-Ling Hsiao
- Li-Chiu Wang (ORCID: https://orcid.org/0000-0001-7201-6026)
- Yi-Ping Tsai
- Ming-Shi Chang
- C.-J. Hung
- Shun-Hua Chen
Institutions
- National Chung Hsing University (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1700154
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00