Tumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancer
Intratumoral NK cell phenotyping may aid in therapeutic stratification in patients with NSCLC. NK<sub>SR</sub> cell preservation predicts benefit from upfront surgery, while NK<sub>AIR</sub> cell enrichment indicates improved response to neoadjuvant chemoimmunotherapy. These NK cell profiles may help optimize treatment by balancing therapeutic benefit and risk.
Authors
- Atsushi Ito (ORCID: https://orcid.org/0000-0003-2345-0146)
- H M Lee
- Jinyoung Byun (ORCID: https://orcid.org/0000-0001-8579-1435)
- Younghun Han
- Bryan M. Burt (ORCID: https://orcid.org/0000-0003-0859-4192)
- Ji Seon Shim (ORCID: https://orcid.org/0000-0001-6655-9614)
- Claire Lee
- Shawn S. Groth (ORCID: https://orcid.org/0000-0001-5745-3703)
- Francesca Polverino (ORCID: https://orcid.org/0000-0001-9686-5698)
- Gena Lee
- F. Kheradmand
- Ayu Hutami Syarif
- Yun Zhang (ORCID: https://orcid.org/0000-0003-4432-6144)
- Sonali Mitra
- Priyanka Ranchod
- Hee-Jin Jang
- Jiyeon Jeon
- R. Taylor Ripley
- Meera Patel
- Christopher I Amos
- Sung Wook Kang
- Joshua Malo
Institutions
- University of Arizona (US)
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Houston Institute for Clinical Research (US)
- New Mexico Cancer Center (US)
- Children's Cancer Center (US)
- Soka Municipal Hospital (JP)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-02
- DOI
- https://doi.org/10.64898/2026.01.01.696292
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- National Cancer Institute