A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction
The iPSC-CMs obtained from the patient carrying a TTN missense mutation and who suffered from VF after STEMI exhibited a decrease in I<sub>Na</sub>, I<sub>Ca-L</sub>, and shortened APD, providing novel insights into the potential electrophysiological mechanisms underlying the development of VF in the context of acute STEMI and TTN mutations.
Authors
- Ying-Ying Ji
- Xiaoxiong Lin (ORCID: https://orcid.org/0000-0002-6212-0249)
- Cheng-Cheng Ji
- Ji Sun (ORCID: https://orcid.org/0000-0002-9302-3177)
- WU Su-hua
- Yun-Jiu Cheng
- Xu-Miao Chen
- Yang Wu
- Li-Juan Liu
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fcvm.2025.1691585
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province