A Novel Polygenic Risk Score Indexing Somatostatin-Expressing Inhibitory Neurons Predicts Somatostatin-Expressing Cell Proportions and Severity of Symptoms in Late-Life Depression
The SST-PRS may serve as a novel biomarker of SST+ neuron pathology and of depressive and cognitive symptom burden in LLD.
Authors
- Kevan Clifford (ORCID: https://orcid.org/0000-0001-5141-0796)
- Benoit H. Mulsant (ORCID: https://orcid.org/0000-0002-0303-6450)
- Eric J. Lenze (ORCID: https://orcid.org/0000-0002-0471-9368)
- Daniel Felsky (ORCID: https://orcid.org/0000-0003-1831-9848)
- Shreejoy J. Tripathy (ORCID: https://orcid.org/0000-0002-1007-9061)
- Yuliya S. Nikolova (ORCID: https://orcid.org/0000-0001-5144-3723)
- Etienne Sibille
- Ayesha S. Syeda
- Xiaolin Zhou
- Alex Gonzalez Segura
- Fernanda C. Dos Santos
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Washington University in St. Louis (US)
- Royal Ottawa Mental Health Centre (CA)
- Hospital Clínic de Barcelona (ES)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100685
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00