Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer
Overexpression of EMT transcription factors SNAI1 and ZEB1 reflect more aggressive histopathological patterns of PDAC. The strong correlation of SNAI1 expression with the expression of other EMT-TFs highlights its' role in peripancreatic invasion, as well as impact on overall survival and may serve as an argument defining the leading role of SNAI1 in this context.
Authors
- Giedrius Barauskas (ORCID: https://orcid.org/0000-0002-4321-7280)
- Aldona Jasukaitienė (ORCID: https://orcid.org/0000-0002-4606-1963)
- Kęstutis Urbonas
- Žilvinas Dambrauskas (ORCID: https://orcid.org/0000-0003-2173-1294)
- Gabija Stachneviciute
- Povilas Ignatavicius
- Antanas Gulbinas
Institutions
- Lithuanian University of Health Sciences (LT)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1371/journal.pone.0339964
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lietuvos Sveikatos Mokslų Universitetas