Timing of Prophylactic Intrapartum Azithromycin Administration and Efficacy in Prevention of Maternal and Infant Infections: A Secondary Analysis of a Randomized Controlled Trial
The benefit observed with a single intrapartum dose of azithromycin for prevention of any maternal infection in the setting of planned vaginal delivery was not observed to vary by time interval from azithromycin administration to delivery, although in some populations there may be greater benefit with delivery > 12 h from administration. Pregnant patients presenting for planned vaginal birth benefit from a single dose of 2 g azithromycin regardless of how soon delivery is anticipated.
Authors
- Janet Moore (ORCID: https://orcid.org/0000-0003-1750-8794)
- Nancy F. Krebs (ORCID: https://orcid.org/0000-0001-5652-7547)
- Rupsa C. Boelig (ORCID: https://orcid.org/0000-0002-3705-6943)
- Denise C. Babineau (ORCID: https://orcid.org/0000-0002-9776-9080)
- Paul Nyongesa (ORCID: https://orcid.org/0000-0002-2896-4720)
- Patricia L. Hibberd (ORCID: https://orcid.org/0000-0002-7455-8117)
- Richard J. Derman (ORCID: https://orcid.org/0000-0003-1148-1594)
- William A. Petri (ORCID: https://orcid.org/0000-0002-7268-1218)
- Elizabeth M. McClure (ORCID: https://orcid.org/0000-0001-8659-5444)
- Lester Figueroa
- Melissa Bauserman (ORCID: https://orcid.org/0000-0002-4992-9895)
- Mrityunjay Metgud (ORCID: https://orcid.org/0000-0002-0844-8569)
- Avinash Kavi (ORCID: https://orcid.org/0000-0002-2176-4697)
- Shivaprasad S. Goudar (ORCID: https://orcid.org/0000-0002-8680-7053)
- Adrien Lokangaka (ORCID: https://orcid.org/0000-0002-8609-5877)
- Dr Manjunath Somannavar
- Manolo Mazariegos (ORCID: https://orcid.org/0000-0002-7485-6413)
- Shiyam Sunder Tikmani (ORCID: https://orcid.org/0009-0001-0523-205X)
- Elwyn Chomba (ORCID: https://orcid.org/0000-0001-7755-9951)
- Musaku Mwenechanya
- Alan T N Tita
- RL Goldenberg
- Sherri Bucher
- Sk Masum Billah
- Waldemar A. Carlo
- Sarah Saleem
- Rashidul Haque
- Archana B. Patel
- Antoinette K. Tshefu
- APLUS Trial Group
- Marion Koso‐Thomas
- Fabian Esamai
Institutions
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- Aga Khan University (PK)
- The University of Sydney (AU)
- Ministry of Public Health (CD)
- Moi University (KE)
- Thomas Jefferson University (US)
- RTI International (US)
- International Centre for Diarrhoeal Disease Research (BD)
- University Teaching Hospital (ZM)
- University of Alabama at Birmingham (US)
- Lata Medical Research Foundation (IN)
- Jawaharlal Nehru Medical College (IN)
- Datta Meghe Institute of Higher Education and Research (IN)
- Institute of Nutrition of Central America and Panama (GT)
- Sydney Local Health District (AU)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Richard M. Fairbanks Foundation (US)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1111/1471-0528.70121
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00