Association between serum γ-Glutamyltransferase and the risk of cervical cancer: Evidence from the national health and nutrition examination survey

Elevated serum GGT levels are associated with a heightened risk of cervical cancer even in HPV-negative patients. Although this association is partly mediated by tobacco exposure, GGT may still play a role in cervical cancer via nontobacco routes. The potential application of GGT as an auxiliary biomarker requires further validation in prospective studies.

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Publication Details

Journal
PLoS ONE
Published
2026-01-02
DOI
https://doi.org/10.1371/journal.pone.0339001
Primary Topic
Sulfur Compounds in Biology
Type
article
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0.00
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article

Association between serum γ-Glutamyltransferase and the risk of cervical cancer: Evidence from the national health and nutrition examination survey

Lu Qiu, Yuanfu Xie, Jianli Huang, Youjia Wang et al.
PLoS ONE
Sulfur Compounds in Biology
article

Association between serum γ-Glutamyltransferase and the risk of cervical cancer: Evidence from the national health and nutrition examination survey

Lu Qiu, Yuanfu Xie, Jianli Huang, Youjia Wang, Yimin Li, Yanhong Zhuo
article en

Abstract

Elevated serum GGT levels are associated with a heightened risk of cervical cancer even in HPV-negative patients. Although this association is partly mediated by tobacco exposure, GGT may still play a role in cervical cancer via nontobacco routes. The potential application of GGT as an auxiliary biomarker requires further validation in prospective studies.

PLoS ONEVol. 21(1)
Fujian Medical University (CN), Zhangzhou Municipal Hospital of Fujian Province (CN)
Openalex Percentile: Top 98%
Sulfur Compounds in Biology
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