Research progress on triterpenoids in the genus <i>Rubus</i> : a comprehensive review

The <i>Rubus</i> genus, a critical resource within the Rosaceae family, exhibits extensive distribution across both temperate and tropical regions. The abundant triterpenoids in these plants have garnered considerable attention due to their diverse structures and important biological activities. To date, a variety of triterpenoids have been extracted, and more than 150 species have been sorted out in this paper, comprising 79 ursanes, 24 oleananes, 15 lupeolanes, 6 cucurbitanes, and 26 other types, with ursanes being predominant. These triterpenoids are rich in bioactive compounds, exhibit pharmacological properties including anti-inflammatory, anticancer, hypoglycaemic, and immune-regulatory effects, traditionally used to treat ailments inflammation, diabetes, and cancer, and have gradually also been applied in agriculture and industry. This paper systematically reviews <i>Rubus</i> triterpenoid advances in structural classification, bioactivities, and analytical techniques. It provides a theoretical foundation for the resource development, in-depth research on pharmacological mechanisms, and the creation of innovative drugs and functional foods.

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Publication Details

Journal
Natural Product Research
Published
2026-01-02
DOI
https://doi.org/10.1080/14786419.2025.2608702
Primary Topic
Natural product bioactivities and synthesis
Type
article
Field-Weighted Citation Impact
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article

Research progress on triterpenoids in the genus Rubus : a comprehensive review

Yuan Fang Li, Le Cai, Yan Luo, Yong-Fan Zi et al.
Natural Product Research
Natural product bioactivities and synthesis
article

Research progress on triterpenoids in the genus Rubus : a comprehensive review

Yuan Fang Li, Le Cai, Yan Luo, Yong-Fan Zi, Xi-Ya Li, Rui-Feng Mei, Ting-Cai Dong
article en

Abstract

The <i>Rubus</i> genus, a critical resource within the Rosaceae family, exhibits extensive distribution across both temperate and tropical regions. The abundant triterpenoids in these plants have garnered considerable attention due to their diverse structures and important biological activities. To date, a variety of triterpenoids have been extracted, and more than 150 species have been sorted out in this paper, comprising 79 ursanes, 24 oleananes, 15 lupeolanes, 6 cucurbitanes, and 26 other types, with ursanes being predominant. These triterpenoids are rich in bioactive compounds, exhibit pharmacological properties including anti-inflammatory, anticancer, hypoglycaemic, and immune-regulatory effects, traditionally used to treat ailments inflammation, diabetes, and cancer, and have gradually also been applied in agriculture and industry. This paper systematically reviews <i>Rubus</i> triterpenoid advances in structural classification, bioactivities, and analytical techniques. It provides a theoretical foundation for the resource development, in-depth research on pharmacological mechanisms, and the creation of innovative drugs and functional foods.

Natural Product Research
Yunnan University (CN), Yunnan University of Traditional Chinese Medicine (CN)
Zero hunger
Openalex Percentile: Top 99%
Natural product bioactivities and synthesis
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