Limited Evidence to Support the Use of Intra-Articular Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Control Trials
This systematic review and meta-analysis indicate that intra-articular HA injections provide limited clinical benefit for ankle OA, with no significant improvements in pain or functional outcomes compared to control treatments. Further high-quality randomized trials are needed to determine the precise role of HA in the management of ankle OA.<b>Levels of Evidence</b>: I, meta-analysis of randomized controlled trials.
Authors
- Bradley A. Lezak (ORCID: https://orcid.org/0000-0001-9802-290X)
- Nathaniel P. Mercer (ORCID: https://orcid.org/0000-0002-2502-9294)
- Kishore Konar (ORCID: https://orcid.org/0009-0006-3643-3694)
- Alexander Tham (ORCID: https://orcid.org/0000-0003-4601-1621)
- John G. Kennedy (ORCID: https://orcid.org/0000-0002-7286-0689)
- Jared M. Rubin (ORCID: https://orcid.org/0009-0004-7000-8726)
- Akram Habibi
- Lana K. Chin
- James J. Butler
Institutions
- NYU Langone Health (US)
- New York University Langone Orthopedic Hospital (US)
Publication Details
- Journal
- Foot & Ankle Specialist
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1177/19386400251403922
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00