Sex-specific effects of peptidyl arginine deiminase 4 deficiency in the cafeteria diet-induced obesity-associated metabolic complications
PAD4 deficiency exerts sex-specific effects on obesity-related metabolic complications in mice. Inhibition of NET formation appears protective in males but not females on an obesogenic diet. These findings underscore the importance of considering sex as a biological variable in obesity research and developing sex-specific therapies.
Authors
- Emőke ŠTEŇOVÁ
- Veronika Borbélyová (ORCID: https://orcid.org/0000-0001-7014-9626)
- Michal Pastorek
- Kristína Macáková (ORCID: https://orcid.org/0009-0003-1593-5175)
- Peter Celec (ORCID: https://orcid.org/0000-0001-5883-3580)
- Katarı́na Šebeková (ORCID: https://orcid.org/0000-0002-9641-9265)
- Roman Gardlík (ORCID: https://orcid.org/0000-0001-8211-907X)
- Andrej Feješ (ORCID: https://orcid.org/0009-0001-8349-6130)
- Emil Bečka
- Ivana Feješ Slivková
Institutions
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fendo.2025.1694559
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agentúra na Podporu Výskumu a Vývoja
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV