Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke
Dynamic analyses targeting interhemispheric interactions are valuable for understanding neural reorganization after stroke. The diminished interactions between the homotopic PMd indicate a compensatory mechanism. Importantly, a state-dependent compensatory pathway was identified, wherein the contralesional PMd assumes the functions of the ipsilesional PMd through enhanced interactions with subcortical structures, potentially guiding more effective interventions.
Authors
- Huaxin Fan
- Craig S. Anderson (ORCID: https://orcid.org/0000-0002-7248-4863)
- Benjamin Becker (ORCID: https://orcid.org/0000-0002-9014-9671)
- Qiurong Yu
- Hewei Wang (ORCID: https://orcid.org/0000-0001-7632-0607)
- Limin Sun
- Nanyu Kuang
- Xinran Wu
- Lili Song
- Zhengxu Lian
- Mingxia Fan
- Jie Zhang
Institutions
- Fujian Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Royal Prince Alfred Hospital (AU)
- Ruijin Hospital (CN)
- Shanghai Institute for Science of Science (CN)
- The George Institute for Global Health (AU)
- First Affiliated Hospital of Fujian Medical University (CN)
- UK Dementia Research Institute (GB)
- George Institute for Global Health (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Imperial College London (GB)
- East China Normal University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Stroke
- Published
- 2026-01-02
- DOI
- https://doi.org/10.5853/jos.2025.01725
- Citations
- 14
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 428.86
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- China Scholarship Council