Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates
This analysis provides a basis for the design of future clinical studies with KLH challenges. These data provide further insights into the performance of the human KLH challenge, which will facilitate the implementation of this immune challenge model in future clinical pharmacology studies.
Authors
- Marieke L. de Kam (ORCID: https://orcid.org/0000-0002-6351-0847)
- Matthijs Moerland (ORCID: https://orcid.org/0000-0002-8064-8426)
- Jacobus Burggraaf (ORCID: https://orcid.org/0000-0001-7912-0918)
- Micha N. Ronner (ORCID: https://orcid.org/0000-0003-2886-2836)
- Mascha Jansen
- Silke Van Reeuwijk
Institutions
- Leiden University Medical Center (NL)
- Centre for Human Drug Research (NL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fphar.2025.1717333
- Primary Topic
- Immunotoxicology and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00