Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA

Early initiation of DAPT was associated with the greatest clinical benefit, consistent with current guideline recommendations. The therapeutic effect appeared to decline progressively beyond this period, with an estimated threshold around 42 hours.

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Publication Details

Journal
Stroke
Published
2026-01-02
DOI
https://doi.org/10.1161/strokeaha.125.053343
Primary Topic
Antiplatelet Therapy and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA

Jeong-Yoon LEE, Ho Geol Woo, Tai Hwan Park, Hong-kyun Park et al.
Stroke
Antiplatelet Therapy and Cardiovascular Diseases
article

Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA

Jeong-Yoon LEE, Ho Geol Woo, Tai Hwan Park, Hong-kyun Park, Han Moon-Ku, Sung Hyuk Heo, Dongwhane Lee, D. Kim, S. J. Lee, Keon‐Joo Lee, Dong-Seok Gwak, Joon-Tae Kim, Minwoo Lee, Jae Guk Kim, Kwang-Yeol Park, Mi-Sun Oh, Jay Chol Choi, Kyungbok Lee, Beom Joon Kim, Hyunsoo Kim, Kang Kyusik, Sang-Soon Park, Jeong-Ho Hong, Wook-Joo Kim, Joong-Goo Kim, Kyumgmi Oh, Hyungjong Park, Kang-Ho Choi, Chi Kyung Kim, Do Yeon Kim, Ji Sung Lee, Hae-Bong Jeong, Yong-Jin Cho, Jong-Moo Park, Doo Hyuk Kwon, Jun Lee, Sung-Il Sohn, Dong-Ick Shin, Hee-Joon Bae, Jae-Kwan Cha, Jaemin Shin, Kyu Sun Yum, on behalf of the CRCS-K-NIH Investigators, Kyung-Ho Yu, Chulho Kim, Keun-Sik Hong, Jee-Hyun Kwon, Juneyoung Lee
article en

Abstract

Early initiation of DAPT was associated with the greatest clinical benefit, consistent with current guideline recommendations. The therapeutic effect appeared to decline progressively beyond this period, with an estimated threshold around 42 hours.

StrokeVol. 57(3)
Eulji University (KR), Dong-A University Hospital (KR), Soonchunhyang University Hospital Seoul (KR), Asan Medical Center (KR), Seoul National University Bundang Hospital (KR), Kyung Hee University (KR), Sacred Heart Hospital (NG), Seoul Medical Center (KR), Chonnam National University Hospital (KR), Dongguk University Ilsan Hospital (KR), Inje University Ilsan Paik Hospital (KR), Ulsan University Hospital (KR), Sacred Heart Hospital (US), Jungwon University (KR), Yeungnam University Medical Center (KR), Kyung Hee University Hospital at Gangdong (KR), Chung-Ang University Hospital (KR), Hallym University Sacred Heart Hospital (KR), Chungbuk National University Hospital (KR), Korea University (JP), Jeju National University Hospital (KR), Keimyung University (KR)
Good health and well-being
Openalex Percentile: Top 99%
Antiplatelet Therapy and Cardiovascular Diseases
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