Early-life tobacco exposure, genetic susceptibility, and multiple digestive diseases: evidence from two large cohorts and genetic analyses
Early-life tobacco exposure significantly increases risks of digestive diseases in two large cohorts, independent of genetic susceptibility and mediated by biological aging acceleration. It also accelerates progression from digestive disease to death, leading to severe outcomes and higher surgical need. Our findings help the identification of high-risk individuals and highlight the importance of preventing tobacco exposure during early life to mitigate digestive disease risk and mortality, and associated surgical burden.
Authors
- Lijun Zhang (ORCID: https://orcid.org/0009-0003-6823-1913)
- Jing Feng (ORCID: https://orcid.org/0000-0001-7018-0770)
- Chongyang Duan (ORCID: https://orcid.org/0000-0001-7973-0353)
- Yuying Ma
- F W Leung
- Yuting Zhu (ORCID: https://orcid.org/0000-0003-4728-9748)
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- Han Zhang (ORCID: https://orcid.org/0000-0001-8883-4103)
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Yan Qin (ORCID: https://orcid.org/0000-0002-0900-883X)
- Weihong Sha (ORCID: https://orcid.org/0000-0003-4180-5211)
- Qinming Li
- Zeng Ruijie (ORCID: https://orcid.org/0000-0002-8047-2045)
- Yu Long
- Dongling Luo
- Yang Li
- Hao Chen
Institutions
- University of California, Los Angeles (US)
- Shantou University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shantou University Medical College (CN)
- VA Sepulveda Ambulatory Care Center (US)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1097/js9.0000000000003967
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49