The Combination of Mineral Salts and Natural Antioxidants Agents Is Highly Effective in Atopic Dermatitis

Fiorella Yori,1 Carlos Sarmiento,1 Javier Gimeno Beltran,2 Ignacio Umbert1 1Umbert Institute of Dermatology, Corachan Clinic, Barcelona, Spain; 2Unit of Pathology SLP, Corachan Clinic, Barcelona, SpainCorrespondence: Ignacio Umbert, Umbert Institute of Dermatology, Corachan Clinic, Plaza Manuel Corachán 4, Barcelona, 08017, Spain, Tel +34-932804755, Email [email protected]: Intrinsic atopic dermatitis (AD) is a chronic inflammatory skin disease with pruritus and eczematous lesions of skin. A long-lasting cycle of itch-scratch roots results in substantial morbidities and discomfort. Treatment of patients with moderate to severe dermatitis is a challenge. To evaluate the efficacy of a treatment based on mineral salts and natural antioxidants agents in patients with AD.Patients and Methods: In this prospective study, 34 patients with AD were treated for 14 days. Patients were evaluated before and after treatment. The effects were studied by the following clinical measurements: Eczema Area and Severity Index (EASI), Scoring Atopic Dermatitis (SCORAD), Body Surface Area (BSA), and Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD). Patient-reported measurements were also assessed: Patient-Oriented Eczema Measure (POEM), Dermatology Life Quality Index (DLQI), and the pruritus Numeric Rating Scale (NRS). Biopsies were performed in 10 patients and immunohistochemistry tests in 7 patients.Results: All clinical and patient-reported measurements showed a strong difference before and after treatment. The epidermis thickness was significantly reduced, as well as the lymphocyte infiltration and the reduction of CD3, CD4, CD8, CD20 and CD117 cells. No adverse events were observed.Conclusion: This study shows that the severity of intrinsic dermatitis was drastically reduced with the treatment of mineral salts and natural antioxidants agents. This topic treatment was very well tolerated without adverse events.Plain Language Summary: Atopic dermatitis is very frequent disease of the skin. The symptoms are itching and eczematous skin lesions. Patients suffering from atopic dermatitis can develop systemic infections, cardiovascular diseases and to some neuropsychiatric conditions, including depression, anxiety and hyperactivity disorders.The most widely used treatment so far are glucocorticoids, which have significant side effects.Based on the effects of Dead Sea Water and magnesium salts, we designed a formula with natural ingredients. We combined mineral salts and antioxidants agents.In our study, we included 34 patients with atopic dermatitis who used our compound for 14 days. All patients showed significant improvement in their skin, as can be seen in the photographs of the 33 patients shown. We have also performed biopsies before and after treatment, showing an important improvement in the skin.In short, we have developed a natural product that has no side effects that moisturizes the skin, cures itching, and has antioxidant activity. keywords: dermatitis, atopic, mineral salts, therapeutics, pruritus, scratching