Pexophagy meets physiology
In this issue, Xiong et al. (https://doi.org/10.1083/jcb.202503169) introduce mouse models that enable tissue-resolved mapping of peroxisome turnover and pexophagy across development, metabolism, and disease. This study reveals striking cell type-specific differences in peroxisome dynamics and establishes a versatile platform for dissecting how pexophagy integrates with mitochondrial quality control and whole-body metabolic homeostasis.
Authors
- Michael J. Clague
Institutions
- University of Liverpool (GB)
- Systems Biology Institute (JP)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1083/jcb.202511183
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00