Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression

These findings do not support a causal relationship between SSRI treatment and risk of BD. Rather, they suggest that the apparent relationship between SSRI treatment and later BD may be a result of unmeasured confounding.

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Publication Details

Journal
BMJ Mental Health
Published
2025-12-01
DOI
https://doi.org/10.1136/bmjment-2025-302146
Primary Topic
Bipolar Disorder and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression

Animesh Talukder, Colm Healy, Ioanna Kougianou, Kirstie O’Hare et al.
BMJ Mental Health
Bipolar Disorder and Treatment
article

Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression

Animesh Talukder, Colm Healy, Ioanna Kougianou, Kirstie O’Hare, Ian Kelleher
article en

Abstract

These findings do not support a causal relationship between SSRI treatment and risk of BD. Rather, they suggest that the apparent relationship between SSRI treatment and later BD may be a result of unmeasured confounding.

BMJ Mental HealthVol. 28(1)
University College Dublin (IE), St John of God Hospital (AU), University of Oulu (FI), University of Edinburgh (GB)
Good health and well-being
Openalex Percentile: Top 31%
Bipolar Disorder and Treatment
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