Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult—A Systematic Review
This systematic review suggests that APOE-ε4 and potentially the G allele of COMT rs4680 are associated with poor cognitive outcomes following brain insults. The type of brain injury does not appear to influence whether genetic variants predispose to favorable or unfavorable cognitive outcomes. Future research may benefit from focusing on these markers, particularly in larger datasets, to validate these findings.
Authors
- Alba Corell (ORCID: https://orcid.org/0000-0002-6329-2392)
- Anja Smits (ORCID: https://orcid.org/0000-0003-4171-2672)
- Thomas Skoglund (ORCID: https://orcid.org/0000-0003-2645-3529)
- Ingvar Rydén (ORCID: https://orcid.org/0000-0002-4366-7337)
- Tora Dunås (ORCID: https://orcid.org/0000-0002-5911-9511)
- Helena Carén (ORCID: https://orcid.org/0000-0002-8584-555X)
- Anna Dénes (ORCID: https://orcid.org/0000-0003-0187-4423)
- Asgeir Store Jakola (ORCID: https://orcid.org/0000-0002-2860-9331)
- Sophia M. Leiss (ORCID: https://orcid.org/0009-0007-4463-5314)
Institutions
- Uppsala University (SE)
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/brb3.71173
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00