Anticancer Compounds from Bacteria Origin (A Review)

Environmental microorganisms can alter or degrade anticancer medications, contributing to the enzymatic inactivation of antineoplastic agents by mycetes. The extensive range of chemical modification capabilities available in our soil isolate library, which can be utilized to alter or decompose medicinal medicines, can be evaluated for novel activity on various therapeutic agents. The selective detoxification of medicines in non-malignant tissues may enhance the quality of life for chemotherapy patients. The utilization of bacteria and bacteria-derived membrane vesicles (MVs) holds significant promise for advancing controllable targeted medication delivery in the fight against cancer. In comparison to conventional drug delivery systems, bacteria and their membrane vesicles possess distinctive attributes as medication carriers for cancer therapy. They can surmount physical obstacles to localize and aggregate in tumor tissues, thereby initiating anticancer immune responses. Additionally, they can be changed through genetic and chemical methods to boost the creation and delivery of anticancer drugs to tumor tissues, which helps make cancer treatment safer and more effective while reducing damage to healthy cells.