Increased transmembrane protein 119 (TMEM119) levels in the cerebrospinal fluid of patients with mild cognitive impairment due to Alzheimer's disease suggest early microglial involvement
Elevated levels of TMEM119 were observed in the CSF of patients with AD.Increased CSF TMEM119 was seen in MCI-AD patients compared to controls.Elevated levels in MCI-AD underscore early microglial involvement in AD.In the AD group, an association was found between CSF TMEM119 and CSF total tau.CSF TMEM119 may provide valuable information on neuroinflammation.
Authors
- Mona Laible (ORCID: https://orcid.org/0000-0002-2836-096X)
- Badrieh Fazeli (ORCID: https://orcid.org/0000-0002-2970-0065)
- Veronika Klose (ORCID: https://orcid.org/0009-0004-1597-2571)
- Paula C. Klassen
- Sarah Jesse (ORCID: https://orcid.org/0000-0001-6235-8145)
- Deborah K. Erhart (ORCID: https://orcid.org/0000-0002-3003-4119)
- Nerea Gómez de San José (ORCID: https://orcid.org/0000-0003-0319-7374)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- André Huss (ORCID: https://orcid.org/0000-0002-2761-7591)
- Franziska Bachhuber (ORCID: https://orcid.org/0000-0003-1031-9966)
- Sarah Anderl‐Straub (ORCID: https://orcid.org/0000-0002-4850-3091)
- Christoforos Alexudis
- Önder Soylu
- Albert C. Ludolph
- Steffen Halbgebauer
- Hayrettin Tumani
Institutions
- German Center for Neurodegenerative Diseases (DE)
- University Hospital in Halle (DE)
- University Hospital Ulm (DE)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/dad2.70240
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00