Olanzapine Overdose in an Adult Male Presenting With Altered Sensorium and Pinpoint Pupil: A Case Report

Olanzapine is an atypical antipsychotic prescribed for various mental illnesses such as psychosis, schizophrenia, depression, and bipolar disorder. An overdose of olanzapine leads to many adverse effects, such as agitation, tachycardia, extrapyramidal dystonia, dysarthria, blurred vision, myosis, hypotension, respiratory depression, and deep coma. Yet, no antidote is available for olanzapine poisoning, and, hence, supportive care is a mainstay of management. A 51-year-old male presented to the emergency department in an unconscious state with an alleged history of drug overuse, with the ingestion of 10 tablets of olanzapine 10 mg. The patient was intubated. After intubation, Ryle's tube was inserted, and gastric lavage was performed using 300 mL of normal saline. The rest of the treatment was supportive. Prompt clinical evaluation, along with thorough history-taking from patients or family members, is a crucial step in patient management and thereby improving the outcome. Increasing awareness among healthcare providers about toxicity due to olanzapine overdose is an important step for assuring early intervention and improving patient care.