Nonlinear association of triglyceride‐glucose body mass index with all‐cause mortality in postmenopausal women, a retrospective cohort study: Evidence from the 2001 to 2014 National Health and nutrition examination survey

In this cohort of US postmenopausal women, TyG-BMI exhibited a U-shaped association with all-cause mortality. Both low and high TyG-BMI values conferred elevated mortality risk, especially from cardiovascular causes, while intermediate TyG-BMI levels were associated with the lowest risk. These findings suggest that maintaining a balanced TyG-BMI, reflecting neither extreme leanness with low metabolic reserves nor excessive insulin-resistant adiposity, might be important for longevity in older women.

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Publication Details

Journal
International Journal of Gynecology & Obstetrics
Published
2025-12-31
DOI
https://doi.org/10.1002/ijgo.70778
Primary Topic
Diabetes, Cardiovascular Risks, and Lipoproteins
Type
article
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article

Nonlinear association of triglyceride‐glucose body mass index with all‐cause mortality in postmenopausal women, a retrospective cohort study: Evidence from the 2001 to 2014 National Health and nutrition examination survey

Xiliang Wang, Chang Tan, Yuexin Yu, Kaiyue Wang
International Journal of Gynecology & Obstetrics
Diabetes, Cardiovascular Risks, and Lipoproteins
article

Nonlinear association of triglyceride‐glucose body mass index with all‐cause mortality in postmenopausal women, a retrospective cohort study: Evidence from the 2001 to 2014 National Health and nutrition examination survey

Xiliang Wang, Chang Tan, Yuexin Yu, Kaiyue Wang
article en

Abstract

In this cohort of US postmenopausal women, TyG-BMI exhibited a U-shaped association with all-cause mortality. Both low and high TyG-BMI values conferred elevated mortality risk, especially from cardiovascular causes, while intermediate TyG-BMI levels were associated with the lowest risk. These findings suggest that maintaining a balanced TyG-BMI, reflecting neither extreme leanness with low metabolic reserves nor excessive insulin-resistant adiposity, might be important for longevity in older women.

International Journal of Gynecology & Obstetrics
General Hospital of Shenyang Military Region (CN)
No poverty
Openalex Percentile: Top 28%
Diabetes, Cardiovascular Risks, and Lipoproteins
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