Evaluation of Homocysteine Level among Women with Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects women of reproductive age, which is characterized by hyperandrogenism, leading to ovarian dysfunction and hyperinsulinemia. Elevated homocysteine (Hcy) levels have been linked to PCOS. Aims of the study: To determine Hcy levels among women with PCOS. Subjects and Methods: This study is a case-control study conducted from January 2024 through April 2024 and involved 200 participants, 100 as patients with PCOS, and 100 women as the control group, who appeared healthy. Blood pressure (BP), body mass index (BMI), waist circumference (WC), plasma Hcy, testosterone, total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were measured in all participants. Results: Pasma Hyc, testosterone, TC, TG, LDL-C were significantly higher among patients with PCOS than control women, P<0.001, while HDL-C was significantly lower among women with PCOS than among controls, P<0.001. Conclusion: Women with PCOS have distinctly higher plasma Hcy concentrations. This may increase the risk of cardiovascular disease among patients with PCOS