Tissue Stem Cell Research of the Larynx and Trachea

In regard to post-injury tissue regeneration of the larynx and trachea, knowledge regarding the cellular composition of normal tissue and maintenance of its homeostasis, which are fundamental for achieving normalization, remains limited. Cell lineage tracing experiments and organoid fabrication methods have enabled the demonstration of stem cell identities by producing all cell types constituting a tissue from a single cell, while retaining self-renewal capacity. By these two methods, several tissue stem cells of the trachea have been identified, while tissue stem cells of the larynx have not been identified yet.