Mechanism of d-Glucaro-1,4-lactone enhancing the anticancer efficacy of lenvatinib via the IFN-γ-STAT3-PD-L1 signaling pathway in hepatocellular carcinoma

1,4-GL potently synergizes with lenvatinib against HCC by enhancing oxidative stress, reconstituting antitumor immunity, and suppressing the STAT3/PD-L1 signaling axis, without perturbing lenvatinib pharmacokinetics. This defines a novel phytochemical-based combinatorial strategy with significant clinical translation potential for HCC therapy.

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Publication Details

Journal
Phytomedicine
Published
2025-12-31
DOI
https://doi.org/10.1016/j.phymed.2025.157760
Primary Topic
Cytokine Signaling Pathways and Interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Mechanism of d-Glucaro-1,4-lactone enhancing the anticancer efficacy of lenvatinib via the IFN-γ-STAT3-PD-L1 signaling pathway in hepatocellular carcinoma

Yufeng Deng, Zhiying Song, Yongrong Lei, Dujuan Zhan et al.
Phytomedicine
Cytokine Signaling Pathways and Interactions
article

Mechanism of d-Glucaro-1,4-lactone enhancing the anticancer efficacy of lenvatinib via the IFN-γ-STAT3-PD-L1 signaling pathway in hepatocellular carcinoma

Yufeng Deng, Zhiying Song, Yongrong Lei, Dujuan Zhan, Baogang Xie, Mengyuan Nie, Zhiguo Wu, Meng Liu, Qi hu
article en

Abstract

1,4-GL potently synergizes with lenvatinib against HCC by enhancing oxidative stress, reconstituting antitumor immunity, and suppressing the STAT3/PD-L1 signaling axis, without perturbing lenvatinib pharmacokinetics. This defines a novel phytochemical-based combinatorial strategy with significant clinical translation potential for HCC therapy.

PhytomedicineVol. 150
Jiangxi University of Traditional Chinese Medicine (CN), Nanchang University (CN), Lishui University (CN), Jiaxing University (CN), Second Affiliated Hospital of Nanchang University (CN), Southern Medical University (CN)
Good health and well-being
Openalex Percentile: Top 29%
Cytokine Signaling Pathways and Interactions
DOIOpen Access PDFOpenAlex
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