Navigating the emotional burden: Addressing anxiety and depression across stages of hepatobiliary and pancreatic malignancies

In this editorial, we comment on the study of the Yu <i>et al</i> on psychological distress in patients with hepatobiliary and pancreatic malignancies. Hepatobiliary and pancreatic malignancies include hepatocellular carcinoma, cholangiocarcinoma, gallbladder cancer and pancreatic cancer. These cancers are among the most aggressive and difficult to treat. Although improvements in surgery, drug treatments and palliative care have led to better survival rates and quality of life, the significant psychological impact on patients remains underrecognized. Anxiety and depression are prevalent at every stage of the disease, from the initial diagnosis to treatment, recurrence and end-of-life care. However, these issues often take a backseat to the urgent need to manage physical symptoms. Mental health challenges can greatly affect how well patients follow treatment plans, recover and their overall outlook. Yu <i>et al</i> explore the causes of psychological distress in hepatobiliary and pancreatic cancers, including disease severity, symptom burden, financial stress and fears about life and death. We highlight the importance of regular mental health screenings, psychological support and teamwork in oncology care. By focusing on emotional health alongside physical treatment, doctors can build resilience, improve outcomes and address a frequently ignored aspect of cancer care.