Multisystem comorbidities and shared genetic pathways in calcific aortic stenosis: a phenome-wide and Mendelian randomisation analysis
CAS is embedded within a broad multisystem comorbidity network, driven largely by genetic variation at LPA and elevated Lp(a). These findings highlight pleiotropic mechanisms linking valvular calcification with systemic disease and support LPA-targeted therapies as a promising avenue for reducing the multisystem burden of CAS.
Authors
- Xingyu Qian
- Mao Chen (ORCID: https://orcid.org/0000-0002-5504-3775)
- Fuqiang Tong (ORCID: https://orcid.org/0000-0002-0470-6698)
- Yidan Zheng
- Y.‐H. Liu (ORCID: https://orcid.org/0000-0002-1466-9691)
- Jingyu Xu (ORCID: https://orcid.org/0000-0002-0545-0444)
- Shiyan Hu
- Lifei Luo
- Zihao Zhou
- Da Zhu
- Zhe Chen
- Pengning Fan
- Li Xu
- Fei Li
- Chen Jiang
Institutions
- Union Hospital (HK)
- Fuwai Yunnan Cardiovascular Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Heart
- Published
- 2025-12-29
- DOI
- https://doi.org/10.1136/heartjnl-2025-326058
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China