Reassessing the 2023 International Society for Cardiovascular Infectious Diseases Duke Clinical Criteria for Infective Endocarditis: Impact of Excluding Fever and Updating Diagnostic Definitions
Exclusion of fever as a minor criterion within the updated Duke-ISCVID framework substantially improved specificity without compromising sensitivity. These findings challenge the traditional role of fever in IE diagnosis and support a broader re-evaluation of longstanding diagnostic criteria.
Authors
- Laurence Senn (ORCID: https://orcid.org/0000-0001-7198-1625)
- Jana Epprecht (ORCID: https://orcid.org/0000-0003-3277-7044)
- Mathias Van Hemelrijck (ORCID: https://orcid.org/0000-0002-0191-757X)
- Berit Siedentop (ORCID: https://orcid.org/0000-0003-0802-7681)
- Barbara Hasse (ORCID: https://orcid.org/0000-0001-7196-3734)
- Elisavet Stavropoulou (ORCID: https://orcid.org/0000-0002-8299-9035)
- G. Tzimas (ORCID: https://orcid.org/0000-0002-2593-5166)
- Pierre Monney (ORCID: https://orcid.org/0000-0002-3083-7333)
- Nicoleta Ianculescu
- Nicolas Fourré (ORCID: https://orcid.org/0009-0006-1660-9365)
- Lars Niclauss (ORCID: https://orcid.org/0000-0003-4453-5202)
- Virgile Zimmermann (ORCID: https://orcid.org/0009-0005-1812-0216)
- M. Frank
- Matthaios Papadimitriou-Olivgeris
- Matthias Kirsch
- Benoit Guery
- Omer Dzemali
Institutions
- University of Zurich (CH)
- Triemli Hospital (CH)
- University Hospital of Zurich (CH)
- Hôpital du Valais (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1093/cid/ciaf737
- Citations
- 1
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung