Single‐nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC)
Distinct Cellular Origins: PSC arises primarily from epithelial (AT2) cells via EMT, whereas PPS is predominantly fibroblast-derived. Prognostic Driver HMGA2: Elevated HMGA2 in malignant AT2 cells correlates with poor prognosis and is significantly higher in MET-mutated PSC. Pathway Divergence in Malignant Cells: Malignant lipofibroblasts in PPS share a similar profile with PSC but uniquely enrich DNA repair pathways.
Authors
- Dongsheng Chen (ORCID: https://orcid.org/0000-0002-7196-4136)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-5848-1922)
- Jun Wei
- Wanglong Deng (ORCID: https://orcid.org/0000-0003-4242-9166)
- Qianqian Duan
- Wenchen Wang
- Shouzheng Ma
- Yanlu Xiong
- Jie Lei
- Qin Zhang
- Jiakuan Chen
- Jianfei Zhu
Institutions
- People 's Liberation Army 451 Hospital (CN)
- Simcere Pharmaceutical (China) (CN)
- Air Force Engineering University (CN)
- Xi'an Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1002/ctm2.70566
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00