Antibiotics and preterm delivery: The prevalent new-user cohort design to resolve immortal time bias

Using the prevalent new-user design, which emulates a randomized trial, antibiotic use late in pregnancy was associated with a modest increased incidence of preterm delivery. Previous inconclusive studies may have resulted from observational methods that introduced, or insufficiently addressed, immortal time bias.

Authors

Samy Suissa (ORCID: https://orcid.org/0000-0002-1281-5296)
E. Comín (ORCID: https://orcid.org/0009-0004-9241-5998)
Jacques Balayla (ORCID: https://orcid.org/0000-0002-0783-8063)
Sophie Dell’Aniello
Simon Galmiche

Institutions

Jewish General Hospital (CA)
McGill University (CA)
University of Milano-Bicocca (IT)

Publication Details

Journal: Epidemiology
Published: 2025-12-26
DOI: https://doi.org/10.1097/ede.0000000000001947
Primary Topic: Preterm Birth and Chorioamnionitis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Antibiotics and preterm delivery: The prevalent new-user cohort design to resolve immortal time bias

Samy Suissa, E. Comín, Jacques Balayla, Sophie Dell’Aniello et al.

Dec 26, 2025

Epidemiology

Preterm Birth and Chorioamnionitis

article

Antibiotics and preterm delivery: The prevalent new-user cohort design to resolve immortal time bias

Samy Suissa, E. Comín, Jacques Balayla, Sophie Dell’Aniello, Simon Galmiche

December 26, 2025article en

Abstract

Using the prevalent new-user design, which emulates a randomized trial, antibiotic use late in pregnancy was associated with a modest increased incidence of preterm delivery. Previous inconclusive studies may have resulted from observational methods that introduced, or insufficiently addressed, immortal time bias.

Epidemiology

Jewish General Hospital (CA), McGill University (CA), University of Milano-Bicocca (IT)

Good health and well-being

Openalex Percentile: Top 28%

Preterm Birth and Chorioamnionitis

DOI Source OpenAlex

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