Cerebral Hemodynamics Are Related to Cortical Brain Morphology in Heart Failure with Reduced Ejection Fraction Independent of Reduced Cardiac Output
<h2>Abstract</h2> This study aimed to investigate whether reduced cerebral blood flow is associated with cortical brain remodeling in HFrEF patients and to assess whether these changes occur independently of decreased cardiac output and correlate with alternative markers of HFrEF severity. The findings suggest that brain remodeling in HFrEF can occur independently of reduced cardiac output, highlighting the importance of other pathophysiological factors. A nuanced understanding of these mechanisms could inform improved diagnostic and therapeutic strategies targeting cardiocerebral interactions.
Authors
- Corey R. Tomczak (ORCID: https://orcid.org/0000-0002-8182-6466)
- Darcy D. Marciniuk (ORCID: https://orcid.org/0000-0003-0166-1452)
- Natasha G. Boyes (ORCID: https://orcid.org/0009-0007-3471-9012)
- Adam M.S. Luchkanych (ORCID: https://orcid.org/0009-0003-0201-0528)
- Cameron J. Morse (ORCID: https://orcid.org/0000-0001-7120-0745)
- Majed Haddad (ORCID: https://orcid.org/0000-0002-9841-8792)
- Michael E. Kelly (ORCID: https://orcid.org/0000-0002-0757-6411)
- Geoffrey Karjala (ORCID: https://orcid.org/0009-0005-6309-7748)
- Alexander Zhai
- Michael D. Nelson
- Allen D. Champagne
- T.Dylan Olver
Institutions
- The University of Texas at Arlington (US)
- Queen's University (CA)
- University of Saskatchewan (CA)
Publication Details
- Journal
- CJC Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.cjco.2025.12.011
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heart and Stroke Foundation of Canada