Real-world safety data of first-line drugs for rheumatoid arthritis: insights from the Portuguese Reuma.pt database
AE related to first-line RA therapies can lead to significant clinical consequences, including treatment discontinuation. Male sex and advanced age were associated with increased AE severity. The most affected systems appear consistent with known drug safety profiles, particularly that of methotrexate; however, the absence of information regarding drug dosage precludes more detailed conclusions. These findings emphasize the need for individualized monitoring strategies and improved pharmacovigilance to optimize long-term treatment safety and adherence in RA management.
Authors
- Ana Cláudia Raposo (ORCID: https://orcid.org/0000-0002-3574-3723)
- João Dias (ORCID: https://orcid.org/0000-0002-5108-0018)
- Luís Inês (ORCID: https://orcid.org/0000-0003-3172-3570)
- Ana Águeda (ORCID: https://orcid.org/0000-0001-9984-8084)
- Ana Catarina Moniz (ORCID: https://orcid.org/0000-0002-7343-1181)
- Patrícia Nero
- Daniel Carvalho (ORCID: https://orcid.org/0000-0003-0108-8887)
- Maria Francisca Magalhães
- Ana Vilar (ORCID: https://orcid.org/0000-0001-8516-7042)
- Ana Valido (ORCID: https://orcid.org/0000-0001-5412-2642)
- Teresa Pinho e Melo (ORCID: https://orcid.org/0000-0002-0375-0101)
- M S Bernardes (ORCID: https://orcid.org/0000-0001-7240-1434)
- Helena Assunção (ORCID: https://orcid.org/0000-0002-8849-3828)
- Carla Campinho Ferreia
- Mourão Am
- Cláudia Miguel
- Manuel Morgado (ORCID: https://orcid.org/0000-0003-2112-2835)
- Inês Sopa (ORCID: https://orcid.org/0009-0003-8072-3451)
- Mariana Emília Santos (ORCID: https://orcid.org/0009-0000-4087-4202)
- Helena Santos (ORCID: https://orcid.org/0000-0003-3682-5840)
- Mariana Diz Lopes
- Susana Almeida
- Pedro Pereira (ORCID: https://orcid.org/0000-0001-7835-4755)
- Ana Cristina Cordeiro
- Marina Oliveira
- Susana Emídio Matias
- Maria Pontes Ferreira (ORCID: https://orcid.org/0009-0008-3831-3527)
- Catarina R Rua
- Duarte Augusto (ORCID: https://orcid.org/0009-0004-9311-8493)
- Carlos Marques Gomes
- Daniel Melim
- Catarina Abreu
- Filipe Pinheiro
- João Lagoas Gomes
- Ana Teodósio Chícharo
- Joana Ramos Rodrigues
- Rita Fonseca
- José Tavares-Costa
- Margarida Oliveira
- Leonor Reynolds
- Filipa Canhão André
- Joaquim Polido Pereira
- Marília Rodrigues
- Filipe Araújo
- José António Pereira Silva
- Maura Couto
- Luís Silva Pires
- Ana Rita Vieira
- Vítor Silvestre Teixeira
- Pedro Miguel Teixeira
- Sara Alves Costa
- Graça Sequeira
- João Aguiar
- Filipa Farinha
- Anita Cunha
- Catarina Silva
- Maria Helena Lourenço
- Jorge Garcia
- Ana Catarina Duarte
- Cátia Duarte
Institutions
- University of Trás-os-Montes and Alto Douro (PT)
- Hospitais da Universidade de Coimbra (PT)
- Hospital Center of Cova da Beira (PT)
- Hospital de São João (PT)
- Instituto Superior de Espinho (PT)
- Universidade Politécnica da Guarda (PT)
- Hospital de Egas Moniz (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Instituto Politécnico de Santarém (PT)
- Hospital do Divino Espírito Santo (PT)
- Centro Hospitalar do Tâmega e Sousa (PT)
- Instituto Português de Malacologia (PT)
- Centro Hospitalar de Lisboa Ocidental (PT)
- Santa Casa de Misericórdia de Marília (BR)
- National Laboratory for Civil Engineering (PT)
- Regione del Veneto (IT)
- Secretaria da Saúde (BR)
- Hospital Braga (PT)
- Hospital Garcia de Orta (PT)
- Hospital de Santa Maria (PT)
- Centro Hospitalar do Porto (PT)
- Escola Secundária de Loulé (PT)
- Cognitive Research (United States) (US)
- Hospital do Desterro (PT)
- Hospital Dr. Nélio Mendonça (PT)
- Hospital CUF Descobertas
- Instituto Português de Reumatologia
- University of Aveiro (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- ARP Rheumatology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.63032/xqfs6110
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00