Autonomic Dysfunction and Risk of Mortality in Early‐Onset Parkinson's Disease
Autonomic impairment affects 63.4% of patients with EOPD and carries a 3-fold higher mortality risk, which increases with every additional autonomic symptom reported. In our cohort, autonomic symptoms appeared most commonly after motor onset, contrasting with prodromal autonomic impairment seen in late-onset Parkinson's disease (LOPD). ANN NEUROL 2026;99:964-975.
Authors
- James H. Bower
- Jeremy K. Cutsforth‐Gregory (ORCID: https://orcid.org/0000-0002-5689-4424)
- Pierpaolo Turcano (ORCID: https://orcid.org/0000-0002-3240-8348)
- Eduardo Elias Benarroch (ORCID: https://orcid.org/0000-0001-7968-5054)
- Aidan F. Mullan (ORCID: https://orcid.org/0000-0001-8076-6935)
- Khaled Ghoniem (ORCID: https://orcid.org/0000-0002-6534-5566)
- Capucine Piat
- Rodolfo Savica
- Emanuele Camerucci
Institutions
- Rush University Medical Center (US)
- Centre Hospitalier Universitaire de Nantes (FR)
- University of Illinois Chicago (US)
- Mayo Clinic in Arizona (US)
- University of Kansas Medical Center (US)
- Mayo Clinic in Florida (US)
- Nantes Université (FR)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/ana.78143
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00