Colorectal Air–Liquid Interface Organoids Preserve Tumour-Immune Architecture and Reveal Local Treg Expansion After PD-1 Blockade
Patient-derived ALI organoids represent a physiologically relevant platform that conserves key structural, immunological, and genomic hallmarks of colorectal cancer. By capturing clinically relevant immune remodeling events, such as Treg expansion following PD-1 blockade, this model provides a powerful tool for dissecting tumour-immune interactions.
Authors
- Julia del Prado-Montero
- Laura Córdoba
- Nieves Mateo (ORCID: https://orcid.org/0000-0002-0717-3049)
- Ramón Cantero-Cid
- Olivia Fernández-Medina
- Jaime Alvarez-Benayas (ORCID: https://orcid.org/0000-0002-1922-7681)
- Jesús Fernández-Felipe (ORCID: https://orcid.org/0000-0002-3944-0797)
- Pablo Mata-Martínez (ORCID: https://orcid.org/0009-0005-0929-3908)
- M. Arranz-Alvarez (ORCID: https://orcid.org/0009-0008-1624-6589)
- Yaiza Pedroche-Just (ORCID: https://orcid.org/0009-0007-9074-7587)
- Francisco J. Cueto (ORCID: https://orcid.org/0000-0002-7457-9583)
- Jaime Fernández-Pascual
- Sandra Nieto-Torrero
- G. Maria
- Esther Díaz
- Daniel Arvelo-Rosario
- Rebeca Abad-Moret
- Eduardo López-Collazo
- Agustín L. Santos
- Roberto Lozano-Rodríguez
- Jaime Valentín-Quiroga
- Paloma Gómez-Campelo
- Verónica Terrón-Arcos
- Carlos del Fresno
- Laura Hurtado-Navarro
- Jesús Jiménez-Rodríguez
Institutions
- Universidad Nacional de Educación a Distancia (ES)
- Hospital Universitario La Paz (ES)
- Universidad Nebrija (ES)
- Hospital La Paz Institute for Health Research (ES)
- Medical Research Network (US)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Cancers
- Published
- 2025-12-30
- DOI
- https://doi.org/10.3390/cancers18010132
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05