Assessment of quality control and effect of radiolysis on the in vivo biodistribution of [177Lu]Lu-PSMA-I&T
The inter-laboratory study confirms that impurities caused by radiolysis can be measured accurately across different institutions, ensuring consistency and reliability in clinical diagnostics and therapy, contributing to improved patient safety. Phosphate buffered HPLC-methods showed no significant benefits in quality control. Increased impurities caused by radiolysis lead to lower tumor-to-kidney ratios, with a decrease in specific tumor binding.
Authors
- S. Koolen
- Jordy R. J. P. van de Merbel
- Carolline Ntihabose
- Else A. Aalbersberg (ORCID: https://orcid.org/0000-0002-4910-3794)
- J. R. de Jong
- Maryana Handula (ORCID: https://orcid.org/0000-0003-2927-5684)
- Debra Stuurman (ORCID: https://orcid.org/0000-0003-4923-1312)
- P. Laverman
- Savanne Beekman
- Eline Hooijman
- Tessa F.F. Ververs
- Nyah Rook
- Corrina de Ridder
- Jeroen J. M. A. Hendrikx
- Erik de Blois
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1186/s41181-025-00414-y
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00