Magnetic Properties of Ferritin at Different Levels of Degradation: Implications for <scp>MRI</scp> ‐Based Iron Quantification in the Brain
R<sub>2</sub>* mapping-derived magnetic susceptibility of ferritin appears to be independent of the structural and magnetic organization of its iron core and shows a linear relationship with total iron content. These findings support the interpretation of ferritin as a simple paramagnet at room temperature, without significant antiferromagnetic contributions. Consequently, susceptibility based postmortem studies focusing on iron accumulation are not affected by autolysis.
Authors
- Snježana Radulović
- Christian Enzinger (ORCID: https://orcid.org/0000-0001-9764-7617)
- Sowmya Sunkara (ORCID: https://orcid.org/0000-0002-9333-475X)
- Christoph Birkl (ORCID: https://orcid.org/0000-0003-3101-4002)
- Stefan Ropele (ORCID: https://orcid.org/0000-0002-5559-768X)
- Michael Stöger‐Pollach (ORCID: https://orcid.org/0000-0002-5450-4621)
- Saška Lipovšek (ORCID: https://orcid.org/0000-0003-2898-7807)
- Gerd Leitinger
- Walter Gössler
Institutions
- University of Vienna (AT)
- Innsbruck Medical University (AT)
- TU Wien (AT)
- University of Graz (AT)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- University of Maribor (SI)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/mrm.70241
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund