Sarcopenia-driven gene model as a clinically actionable prognostic signature for head and neck squamous cell carcinoma
Sarcopenia is significantly associated with poorer prognosis in HNSCC. Sarcopenic patients exhibit distinct gene expression, transcriptomic profiles related to lipid metabolism, and immune infiltration levels compared to non-sarcopenic patients. A GRS model constructed with four genes demonstrated favorable performance in predicting prognosis in HNSCC.
Authors
- Kun Gao (ORCID: https://orcid.org/0000-0003-0323-4219)
- Ge Song (ORCID: https://orcid.org/0009-0001-8359-7687)
- Zheran Liu
- Jitao Zhou
- Meng Dou
- Jiagang He
- Jiacheng Li
- Ping Ai
Institutions
- Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tcr-2025-1310
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00