Glutamine metabolism drives tumor aggressiveness but not chemoresistance in ovarian carcinoma cell lines
Intense glutaminolysis is associated with increased tumor aggressiveness, suggesting a prognostic role for <sup>18</sup>F-(2S,4R)-4-fluoroglutamine (<sup>18</sup>F-fluoroglutamine) positron emission tomography (PET) imaging. Glutamine supplementation, without impacting chemoresistance, may mitigate iatrogenic effects, while targeting glutaminolysis offers a therapeutic perspective.
Authors
- Siegfried Hélage (ORCID: https://orcid.org/0000-0001-9876-2633)
- Antonin Ginguay
- M.-C. Blanc-Quintin
- Élisabeth Dion (ORCID: https://orcid.org/0000-0002-7135-1591)
- François Goldwasser (ORCID: https://orcid.org/0000-0003-1503-0723)
- Jean-Pascal De Bandt
- Nathalie Neveux
- Luc Cynober
- Jérôme Alexandre
Institutions
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tcr-2025-1721
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00