Targeting P4HA1 Inhibits Colorectal Cancer Growth, Metastasis, and Tumor‐Associated Macrophage Infiltration via P4HA2‐PI3K‐AKT Pathway
Our findings elucidate the importance of the P4HA1-P4HA2-PI3K-AKT axis in CRC and identify P4HA1 as a promising therapeutic target to impede CRC growth and metastasis while altering the tumor immune landscape. This research provides a foundation for further investigations into P4HA1-targeted therapies, which may improve clinical outcomes for patients with CRC.
Authors
- Nanlin Cao
- Y Li
- Zhijie Chen (ORCID: https://orcid.org/0000-0003-4682-5625)
- Y. Hu (ORCID: https://orcid.org/0000-0003-2188-5920)
- Zuliang Deng
Institutions
- Xiangnan University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/iid3.70315
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province