The Peak Plasma Concentration (Cmax)/Minimum Inhibitory Concentration (MIC) of bedaquiline and levofloxacin with special attention to the sputum conversion in the treatment of multidrug-resistant tuberculosis in Indonesia
Cmax/MIC of bedaquiline was higher in MDR-TB patients with sputum conversion compared to those without conversion within the first four months of treatment, suggesting a potential relationship between Cmax/MIC of bedaquiline and sputum conversion, which was not seen in the levofloxacin cases. However, the application of clinical practice should be carefully considered and supported by further study in various settings.
Authors
- Nina Mariana
- Erni Juwita Nelwan (ORCID: https://orcid.org/0000-0003-4064-5412)
- Rosamarlina Rosamarlina
- Budiman Bela (ORCID: https://orcid.org/0000-0002-9010-2427)
- Vivi Setiawaty (ORCID: https://orcid.org/0000-0002-1196-7909)
- Anggi Gayatri (ORCID: https://orcid.org/0000-0001-9912-0800)
- Vithal Prasad Myneedu
- Soedarsono Soedarsono
- Indah Suci Widyahening
- Iin Maemunah
- Purwantyastuti Ascobat
Institutions
- Nepal Medical College Teaching Hospital (NP)
- University of Indonesia (ID)
- National Brain Centre (ID)
- Kementerian Kesehatan Republik Indonesia (ID)
- Universitas Dr. Soetomo (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Universitas Hang Tuah (ID)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1371/journal.pone.0336210
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Indonesia
- Lembaga Pengelola Dana Pendidikan