Optimizing Prolonged (6 h) Normothermic Machine Perfusion of Donor Kidneys ( <scp>PROPER</scp> Study)
The presented protocol shows prolonging NMP of donor kidneys to 6 h is feasible. We have implemented pivotal elements including the use of fresh (≤ 7 days) washed red blood cells, the addition of albumin, and urine recirculation, resulting in a stable and balanced perfusion. Ongoing refinements are necessary to enable the clinical application of a more prolonged NMP.
Authors
- Cyril Moers (ORCID: https://orcid.org/0000-0001-8014-8387)
- T. Rabelink
- Asel S. Arykbaeva (ORCID: https://orcid.org/0000-0002-2918-171X)
- H. Leuvenink
- Veerle A. Lantinga (ORCID: https://orcid.org/0000-0002-6931-2825)
- Robert C. Minnee (ORCID: https://orcid.org/0000-0002-9494-3717)
- Marten A. Engelse (ORCID: https://orcid.org/0000-0003-1341-8521)
- Jason B. Doppenberg (ORCID: https://orcid.org/0000-0001-7375-0839)
- Robert A Pol
- Alwayn Ian P. J.
- Jesper Kers
- Rutger J. Ploeg
- Dorottya K. de Vries
- Volkert A. L. Huurman
- L. Leonie van Leeuwen
Institutions
- Loyola University Medical Center (US)
- University Medical Center Groningen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University of Oxford (GB)
- Amsterdam Neuroscience (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Artificial Organs
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1111/aor.70080
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Nierstichting
- Leids Universitair Medisch Centrum
- Universitair Medisch Centrum Groningen