Rg1-R1 attenuates cardiac ischemia/reperfusion-induced endothelial cell injury through activating the ULK1/PGAM5-FUNDC1-mitophagy pathway
Our results indicated that Rg1-R1 attenuates MIRI-induced endothelial cell injury through activating the ULK1/PGAM5-FUNDC1-mitophagy pathway, and may represent a novel therapeutic target in the context of MIRI.
Authors
- Xiayinan Song
- Danyang Wang (ORCID: https://orcid.org/0000-0001-9673-089X)
- Chao Li
- Jinlan Deng
- Zhenzhen Zheng
- Jie Li
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.jgr.2025.100973
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00