Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm
Olfr2 regulates monocyte recruitment and macrophage-driven inflammation during AAA. Its genetic deletion or pharmacological inhibition protects against AAA, whereas receptor activation worsens the disease. Olfr2 represents a critical modulator of vascular inflammation and a potential therapeutic target in AAA.
Authors
- Philipp Wollnitzke (ORCID: https://orcid.org/0000-0002-0116-546X)
- Norbert Gerdes (ORCID: https://orcid.org/0000-0002-4546-7208)
- Marco Orecchioni (ORCID: https://orcid.org/0000-0002-3602-8510)
- Gerhard Sengle (ORCID: https://orcid.org/0000-0003-3932-1242)
- Harshal Nemade (ORCID: https://orcid.org/0000-0002-2704-181X)
- Dennis Wolf (ORCID: https://orcid.org/0000-0003-1525-4348)
- Dennis Mehrkens (ORCID: https://orcid.org/0000-0002-8578-0290)
- Patrik Schelemei (ORCID: https://orcid.org/0000-0001-5532-5265)
- Ulrich Flögel (ORCID: https://orcid.org/0000-0001-7181-4392)
- Moritz Lindquist Liljeqvist
- C Weber
- Muntadher Al Zaidi (ORCID: https://orcid.org/0000-0002-3534-3121)
- Henning Guthoff (ORCID: https://orcid.org/0000-0002-0979-1190)
- Felix S.R. Picard (ORCID: https://orcid.org/0000-0001-7624-4704)
- Sebastian Zimmer (ORCID: https://orcid.org/0000-0002-1531-2088)
- Thomas Riffelmacher (ORCID: https://orcid.org/0000-0002-0372-5272)
- A Hillmer
- Wiebke Ibing
- Per Arkenberg
- Martin Mollenhauer (ORCID: https://orcid.org/0000-0002-3331-1046)
- Mohammad Karimpour (ORCID: https://orcid.org/0000-0002-7589-9984)
- Kristel Martinez Lagunas
- Bodo Levkau
- Jan Wrobel
- Holger Winkels
- Khalia Cummings
- Markus U. Wagenhäuser
- Sebastian Karl Lechner
- Remco T.A. Megens
- Stephan Baldus
- Hubert Schelzig
- Anna Christine Koebele
- Alexander Hof
- Elena Wagner
- Joy Roy
- Yein Park
Institutions
- MACOM (United States) (US)
- Karolinska University Hospital (SE)
- University of Freiburg (DE)
- Augusta University (US)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- Karolinska Institutet (SE)
- Maastricht University (NL)
- Augusta University Health (US)
- Düsseldorf University Hospital (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1161/circresaha.125.326591
- Citations
- 1
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52